Dr. Shuai Yu
Founder, Chief Scientist
About Dr. Yu
Dr. Yu is a distinguished professional in the field of Biomedical Engineering who has earned his PhD degree from the University of Texas at Arlington and master's degree from the University of Southern California. His focus has been deeply entrenched in biomedical optical and acoustic sensing and imaging. Dr. Yu exhibits a lifetime passion pursuing safe and cost-effective health monitoring, particularly in areas such as diabetes, wound care, and early-stage cancer diagnosis.
Dr. Yu serves as a biomedical R&D scientist in both industrial and research institutes, showcasing his commitment to pushing the boundaries of innovation. As he said, "Innovation stands as the cornerstone of the technology development. While profit is a common pursuit in the medical industry, our distinct emphasis on patient-oriented healthcare propels us to new heights in redefining the standards."
Dr. Yu's Expertise
Ultrasound-Fluorescence Imaging
Novel ultrasound-modulated fluorescence imaging that achieves microscopic resolution at centimeter-deep tissue phantom. See more details at Dr. Yu's dissertation "Ultrasound Switchable Fluorescence Imaging Based on a Time Gated ICCD Camera".
Photoplethysmogram Through Mobile Camera
Science can be simple in our daily lives. Yes, you can visualize your blood flow and measure your heart rate simply non-contact through a mobile video. It is based on photoplethysmogram (PPG) imaging: in this demo, it is also implemented with a robust motion reduction method that significantly improves the signal-to-noise ratio. Check out more with our team if you have interest on similar topics.
Novel Fluorescent Probes
Fluorescent probes can apply a key role in many biomedical applications. Dr. Yu developed several thermal sensitive fluorescent probes that can be used in medical imaging, in-vivo temperature monitoring, cancer tracking, and drug delivery. Check out more details from the publications.
Near-infrared temperature-switchable fluorescence nanoparticles
New generation ICG-based contrast agents for ultrasound-switchable fluorescence imaging
A Biocompatible and Near-Infrared Liposome for In Vivo Ultrasound-Switchable Fluorescence Imaging
Temperature-sensitive polymeric nanogels encapsulating with β-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging
Books
Cutting-edge Technologies in Biological Sensing and Analysis (2023)
Chapter 6 Novel Imaging Contrast Agents and Systems for Biomedical Sensing
Shuai Yu, J.-C. Chiao
River Publishers, 2023.
Dr. Yu's Publications
Patents
Shuai Yu, Jason Dwight, Hanh Le, Jeffrey E Thatcher, Wensheng Fan
US Patent App. 18/470,318, 2024
SYSTEMS AND METHODS FOR THERMOMETRY AND THERANOSTIC APPLICATIONS (2021).
Baohong Yuan, Shuai Yu, Tingfeng Yao
US Patent 11,022,500, 2021
Journals
Shuai Yu, Baohong Yuan
Journal of Biophotonics, e202300533
Shuai Yu, Jason Dwight, Robert C Siska, Heather Burkart, Peiran Quan, Faliu Yi, Shimeng Du, Yahya Daoud, Kevin Plant, Anthony Criscitiello, Joseph Molnar, Jeffrey E Thatcher
Burns 50 (1), 115-122
John J Squiers, Jeffrey E Thatcher, David S Bastawros, Andrew J Applewhite, Ronald D Baxter, Faliu Yi, Peiran Quan, Shuai Yu, J Michael DiMaio, Dennis R Gable
Journal of Vascular Surgery 75 (1), 279-285
Near-infrared temperature-switchable fluorescence nanoparticles (2021)
Shuai Yu, Zhen Wang, Tingfeng Yao, Baohong Yuan
Quantitative Imaging in Medicine and Surgery 11 (3), 1010-1022
Ruilin Liu, Tingfeng Yao, Yang Liu, Shuai Yu, Liqin Ren, Yi Hong, Kytai T Nguyen, Baohong Yuan
Nano Research 13, 1100-1110
Amirhossein Hakamivala, Kayti Robinson, YiHui Huang, Shuai Yu, Baohong Yuan, Joseph Borrelli Jr, Liping Tang
Bioactive materials 5 (1), 142-152
In vivo ultrasound-switchable fluorescence imaging using a camera-based system (2020)
Shuai Yu, Tingfeng Yao, Yang Liu, and Baohong Yuan
Biomedical Optics Express 11 (3), 1517-1538
Yang Liu, Tingfeng Yao, Wenbin Cai, Shuai Yu, Yi Hong, Kytai T Nguyen, Baohong Yuan
Advanced Healthcare Materials 9 (4), 1901457
An ICCD camera-based time-domain ultrasound-switchable fluorescence imaging system (2019)
Shuai Yu, Tingfeng Yao, Baohong Yuan
Scientific Reports 9 (1), 10552
In vivo ultrasound-switchable fluorescence imaging (2019)
Tingfeng Yao, Shuai Yu, Yang Liu, Baohong Yuan
Scientific Reports 9 (1), 9855
Ultrasound-Switchable Fluorescence Imaging via an EMCCD Camera and a Z-Scan Method (2018)
Tingfeng Yao, Shuai Yu, Yang Liu, Baohong Yuan
IEEE Journal of Selected Topics in Quantum Electronics 25 (2), 1-8
Modulation of ultrasound-switchable fluorescence for improving signal-to-noise ratio (2017)
Jayanth Kandukuri, Shuai Yu, Tingfeng Yao, Baohong Yuan
Journal of Biomedical Optics 22 (7), 076021-076021
Bingbing Cheng, Venugopal Bandi, Shuai Yu, Francis D’Souza, Kytai T Nguyen, Yi Hong, Liping Tang, Baohong Yuan
International Journal of Molecular Sciences 18 (2), 384
Jayanth Kandukuri, Shuai Yu, Bingbing Cheng, Venugopal Bandi, Francis D’Souza, Kytai T Nguyen, Yi Hong, Baohong Yuan
International Journal of Molecular Sciences 18 (2), 323
New generation ICG-based contrast agents for ultrasound-switchable fluorescence imaging (2016)
Shuai Yu, Bingbing Cheng, Tingfeng Yao, Cancan Xu, Kytai T Nguyen, Yi Hong, Baohong Yuan
Scientific Reports 6 (1), 35942
Conferences
Feasibility of Deep Learning Combined with Multispectral Imaging for Intra-operative Guidance in Burn Excision Surgery.
Southern Region Burn Conference, New Orleans, LA, November 4th – 7th, 2021.
The poster presentation was awarded the 1st place.
Shuai Yu, Jason Dwight, Peiran Quan, Faliu Yi, Shimeng Du, Brian McCall, Yahya Daoud, Kevin Plant, Maria Cadic, Robert C. Siska, Anthony Criscitiello, Heather DeLoid, Wensheng Fan, Joseph Molnar, Jeffrey E. Thatcher
An AI-powered non-invasive imaging device for image-guided burn excision surgery.
Military Health System Research Symposium, Kissimmee, FL, August 24th – 27th, 2020.
Shuai Yu, Jason Dwight, Brian McCall, Faliu Yi, Peiran Quan, Ronald Baxter, Heather DeLoid, Michelle Harp, Wensheng Fan, J. Michael DiMaio, Joseph Molnar, Jeffrey E. Thatcher
ICG-loaded Liposomes for Ultrasound-Switchable Fluorescence Imaging.
Biomedical Engineering Society Annual Meeting, Philadelphia, PA, October 16th – 19th, 2019.
Yang Liu, Wenbin Cai, Tingfeng Yao, Shuai Yu, Ruilin Liu, Liqin Ren, Kytai T. Nguyen, Yi Hong, Baohong Yuan
In vivo ultrasound-switchable fluorescence imaging in mice.
Society of Photographic Instrumentation Engineers: Photonics West, San Francisco, CA, February 5th – 7th, 2019
Baohong Yuan, Tingfeng Yao, Shuai Yu
A camera-based in-vivo focused-ultrasound switchable fluorescence imaging.
6th International Symposium on Focused Ultrasound, Reston, VA, October 21st – 25th, 2018.
Shuai Yu, Tingfeng Yao, Yang Liu, Baohong Yuan
Surface functionalization of ICG-encapsulated PNIPAM nanoparticles for molecular ultrasound-switchable fluorescence imaging.
Biomedical Engineering Society Annual Meeting, Atlanta, GA, October 17th – 20th, 2018.
Yang Liu, Shuai Yu, Tingfeng Yao, Baohong Yuan
In Vivo Ultrasound-switchable Fluorescence Imaging.
Biomedical Engineering Society Annual Meeting, GA, October 17th – 20th, 2018.
Tingfeng Yao, Shuai Yu, Yang Liu, Baohong Yuan
Camera Based Ultrasound-switchable Fluorescence Imaging System.
Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 11th – 14th, 2017.
Tingfeng Yao, Shuai Yu, Baohong Yuan
Temperature-switchable near-infrared fluorescence nano-capsules.
Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 11th – 14th, 2017.
Shuai Yu, Zhen Wang, Tingfeng Yao, Baohong Yuan
Near-infrared time-domain ultrasound-switchable fluorescence imaging.
OSA Biophotonics Congress: Optics in the Life Sciences, San Diego, CA, April 2nd – 5th, 2017.
Shuai Yu, Yuan Liu, Jayanth Kandukuri, Tingfeng Yao, Baohong Yuan
Improve axial resolution of ultrasound-switchable fluorescence technique for deep-tissue high-resolution fluorescence imaging.
Society of Photographic Instrumentation Engineers: Medical Imaging, San Diego, CA, February 27th – March 3rd, 2016.
Baohong Yuan, Jayanth Kandukuri, Bingbing Cheng, Shuai Yu, Venugopal Bandi, Kytai T. Nguyen, Yi Hong, Francis D’Souza
Modulation of fluorescence via ultrasound-switchable fluorescence for deep-tissue high-resolution imaging.
Society of Photographic Instrumentation Engineers: Medical Imaging, San Diego, CA, February 27th – March 3rd, 2016.
Baohong Yuan, Jayanth Kandukuri, Bingbing Cheng, Shuai Yu, Venugopal Bandi, Kytai T. Nguyen, Yi Hong, Francis D’Souza
A time-domain fluorescence lifetime measurement system for quantifying ultrasound-switchable fluorescence contrast agents.
Biomedical Engineering Society Annual Meeting, Tampa, FL, October 7th – 10th, 2015.
Shuai Yu, Yuan Liu, Bingbing Cheng, Venugopal Bandi, Francis D’Souza, Kytai T. Nguyen, Yi Hong, Baohong Yuan
Stability study of Ultrasound-Switchable Fluorescence contrast agents: ICG-encapsulated poly(Nisopropylacrylamide) nanoparticles.
OSA Biophotonics Congress: Optics in the Life Sciences, Vancouver, Canada, April 12th –15th, 2015.
Shuai Yu, Ming-Yuan Wei, Bingbing Cheng, Kytai T. Nguyen, Yi Hong, and Baohong Yuan